Around five thousand years ago (CF) merged into the human genome, and it has survived and slowly but efficiently spread around the world. It has been said that CF is the combination of more than 1600 mutations. That doesn't mean everybody has (CF), it just means there are certain people who have this disease. Most of these people would be carriers passing the genes generation to generation, but only 25% of the time can the carrier can actually be affected.
Most people don't know but Cystic Fibrosis is actually passed down to them through their parent's genes. (CF) is a mutation in the genes that is passed down from one generation to another by their genes. If a woman who had (CF) were to marry a man without the disease, the children of the couple would inherit the bad genes. The disease wouldn't affect the children, but the mutated genes would remain in the children and their children, and would occur vise versa if the man had the mutated genes.
Cystic Fibrosis affects the body by interfering with the bodies endocrine glands. The endocrine gland's jobs are to produce some of the body's liquid such as tears, mucus, sweat and saliva. Once the disease is active it disrupts the very sensitive balance of chloride, sodium and water contained in cells, which causes the (CF) victims to have sticker fluids in their body. All of that generates to the patient having a large problem with their lungs, pancreas and even the digestive system.
These are the common affects of Cystic Fibrosis. People who actually have CF (not carriers) aren't affected by in there looks or built when affected by (CF), they look as normal and healthy as possible. But these people who are affected have to take great repercussions to make sure they don't catch any harmful bacteria or bugs. This is why who people who are affected (not carriers) should never meet because they could transfer unwanted bugs and bacteria.
Before the 20TH there was little to no data on Cystic Fibrosis at all. Humans who were affected by the disease died with out any medical help for there was none back in those days. It was only until 1938 that an American Pathologist Dr. Dorothy Anderson first came up with the official name and description of CF. After that formal discovery scientist managed to provide better healthcare for the affected, and now there had been a great increase in survival rate thank to the established therapies on CF.